Specific features of viral hepatitis in patients with HIV infection
نویسندگان
چکیده
V lĂŠÄbÄ infekce virem lidskĂŠ imunodeficience (HIV) bylo jiĹž pĹed delĹĄĂ dobou dosaĹženo nÄkolika zlomovĂ˝ch momentĹŻ, kterĂŠ vedly k vĂ˝znamnĂŠmu zlepĹĄenĂ prognĂłzy HIV pozitivnĂch pacientĹŻ, a zĂĄroveĹ tak umoĹžnily soustĹedit pozornost na faktory mortality nesouvisejĂcĂ primĂĄrnÄ s HIV. UkĂĄzalo se, Ĺže zĂĄsadnĂ roli zde hraje mortalita hepatĂĄlnĂ, zejmĂŠna onemocnÄnĂ zpĹŻsobenĂĄ viry hepatitidy B (HBV) C (HCV). PĹĂpady koinfekce jednĂm nebo obÄma v dobÄ diagnĂłzy jsou velmi ÄastĂŠ Äasto takĂŠ zachycovĂĄny nĂĄslednĂŠ pĹĂpady reinfekcĂ HCV. VĂ˝znamnou prevenci HBV obecnÄ vakcinace, jejĂĹž vĂ˝sledek je ovĹĄem u tomto specifickĂŠm pĹĂpadÄ nejistĂ˝; lĂŠÄba pak probĂhĂĄ veskrze formou zaĹazenĂ tenofoviru do lĂŠÄebnĂŠ kombinace antiretrovirovĂ˝ch lĂŠkĹŻ. Pro dlouhodobĂŠ pĹetrvĂĄvĂĄnĂ protilĂĄtek a-HCV jejich opoĹždÄnou tvorbu pacientĹŻ testovĂĄnĂ pĹĂtomnosti HCV metodou polymerĂĄzovĂŠ ĹetÄzovĂŠ reakce (PCR). PĹechod z klasickĂŠ lĂŠÄby chronickĂŠ interferonem ĂŠry antivirotik pĹĂmo pĹŻsobĂcĂch (direct acting antivirals, DAA) umoĹžĹuje souÄasnosti bezpeÄnou, nekomplikovanou univerzĂĄlnÄ ĂşÄinnou lĂŠÄbu koinfikovanĂ˝ch de facto bez ohledu stupeĹ jaternĂho onemocnÄnĂ.
منابع مشابه
Viral hepatitis in HIV infection.
From the Division of Infectious Disease, Beth Israel Deaconess Medical Center, and Harvard Medical School — both in Boston (M.J.K.); and the Division of Gastroenterology, University of California at San Francisco, San Francisco (M.G.P.). Address reprint requests to Dr. Koziel at the Harvard Institutes of Medicine, Rm. 223a, 330 Brookline Ave., Boston, MA 02215, or at [email protected].
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ژورنال
عنوان ژورنال: Medicína pro praxi
سال: 2021
ISSN: ['1803-5310', '1214-8687']
DOI: https://doi.org/10.36290/med.2021.028